The Vulnerable Plaque “Hypothesis”
نویسندگان
چکیده
منابع مشابه
The vulnerable plaque "hypothesis": promise, but little progress.
A PubMed search using the terms “vulnerable plaque” or “high-risk” plaque yields 2,000 references to journal articles published over the past 20 years. Indeed, few concepts in cardiovascular medicine have achieved such intense scientific interest over such a long duration. During this 20-year period, many diagnostic techniques designed to “detect” vulnerable plaques have come and gone. In each ...
متن کاملImaging the vulnerable plaque.
Cardiovascular diseases are still the primary causes of mortality in the United States and in Western Europe. Arterial thrombosis is triggered by a ruptured atherosclerotic plaque and precipitates an acute vascular event, which is responsible for the high mortality rate. These rupture-prone plaques are called "vulnerable plaques." During the past decades, much effort has been put toward accurat...
متن کاملRequiem for the 'vulnerable plaque'.
The concept of the so-called ‘vulnerable plaque’ has proved highly useful to guide research and thinking regarding the pathophysiology of the acute coronary syndromes (ACS). Yet, the time may have come to reconsider this construct, as knowledge has accumulated, the risk profile of the populace has shifted, and our current therapies have reshaped the disease. Over the last several decades, the q...
متن کاملNeuroimaging of the Vulnerable Plaque
Plaque vulnerability due to inflammation has been shown to be a participating factor in the degenerative process in the arterial wall that contributes to stenosis and embolism. This is believed to have an important role to play also in the genesis of stroke or cerebrovascular diseases. In order to appropriately screen patients for treatment, there is an absolute need to directly or indirectly v...
متن کامل[From vulnerable plaque to vulnerable patient].
Atherosclerotic plaque instability is directly involved in triggering acute coronary syndromes, including unstable angina, acute myocardial infarction, and sudden coronary death. Different and not completely unknown mechanisms are involved in the pathogenesis of the destabilisation of the vulnerable plaque; currently three mechanisms are considered to play a causal role in this process: emboliz...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Imaging
سال: 2009
ISSN: 1936-878X
DOI: 10.1016/j.jcmg.2008.12.015